What is Nitric Oxide (NO)?

Nitric Oxide is a small gas molecule composed of oxygen and nitrogen (formula NO) produced naturally in our body by various cell types. In addition to its physiological role of enhancing blood flow and circulation, NO acts as a “killer” molecule, as part of our body’s defense mechanism against foreign pathogens such as bacteria, viruses, parasites and fungi.

How is NO administered to patients?

NO gas is balanced with nitrogen. At the time of administration, NO is blended with oxygen and delivered by inhalation using AIT’s proprietary, state-of-the-art delivery system to ensure it reach the patients’ lungs directly.

What effect does NO have on bacteria?

NO is a powerful broad-spectrum antibacterial agent. NO directly eliminates multiple bacterial strains, including antibiotic-resistant bacteria, and diffuses bacterial colonies, thus increasing their vulnerability to antimicrobials. NO elicits antibacterial activities via several mechanisms. It may stimulate cellular mechanisms to cause bacterial DNA damage and destruction of bacterial membrane. NO can also directly inactivate and neutralize important bacterial proteins.

Can bacteria develop resistance to NO?

To date, bacteria’s ability to develop resistance to inhaled NO has yet to be demonstrated. Studies show that bacteria have not mutated to become less sensitive to NO even after long-term exposure to low non-lethal doses of NO.