– Edward Teller
Developing Nitric Oxide-based products and delivery systems for the treatment of respiratory infections and diseases
Nitric oxide (NO) is a naturally produced gas molecule which plays a critical role in physiological and pathological processes in the body. As a vasodilator, NO enhances blood flow and circulation. In addition, it is involved in regulation of wound healing and immune responses to infection.
In the immune system, NO provides a first line of defense against invading pathogens. NO has been found effective against multiple microbial and viral strains involved in severe lung pathologies such as Cystic Fibrosis (CF) and bronchiolitis. The pharmacology, toxicity and safety data for NO in humans is generally well known. The FDA has approved its use for a number of therapeutic applications.
Advantages of NO as an anti-infection agent:
- Naturally produced substance in the body, short half-life, very low toxicity
- Broad scope of antimicrobial activity against bacteria, viruses and fungi
- Not an antibiotic drug, no implications of resistance
- A vasodilator that enhances circulation and the supply of immune cells to the treated area
Therapeutic use of NO for viral and bacterial co-infections has the potential of mimicking the body’s natural defense mechanism and can directly reduce viral infectivity and eliminate drug-resistant bacteria.
AIT’s proprietary technology enables safe and efficient delivery of therapeutic inhaled NO to patients suffering from respiratory diseases and infections.